DesBio Liposomal and Micellular Formulas Micelles and liposomes are both delivery systems and work in very similar ways. They both increase the bioavailability of supplements by shielding, protecting, and delivering them through the digestive system and into the bloodstream. The main difference between these two delivery systems is that micelles have a single layer membrane, whereas liposomes have a bilayer. In terms of their actual functioning, liposome formulations and micelles are similar. Some vitamins and nutrients are better suited for using liposomal methods, while some are more suited for a micellular formula.

Why Micellular Immune Attune?

Micellular Immune Attune offers an exciting and compelling blend of vitamins and herbs to promote optimal immune, cardiovascular, and healthy aging support packaged in a patented micro-encapsulation delivery system.^1,2 This formula combines the benefits of Vitamins C, D, E, and a well-tolerated and well-absorbed zinc chelate, with powerfully beneficial herbals to promote overall immune system health.

This multi-faceted combination of vitamins and herbs supports innate and adaptive immunity by priming natural killer cells and immune cell communication pathways.^1,2 The ingredients also fortify the body’s antioxidant and defense systems and support a healthy stress response.^1,2 A great-tasting liquid-berry formula, Immune Attune is suitable for the entire family as a source of daily immune support or to support healthy aging.

The Need for Micellular Immune Attune Supplementation

Sambucus nigra/canadensis (Black Elderberry)

Elderberry uses are manifold and important. Elderberry fruit and leaves contain numerous compounds thought to have immune-priming effects.³ Several double-blind placebo-controlled studies using standardized elderberry extracts in the test groups have yielded positive results, supporting numerous markers of healthy immune activity. ^4,5,6

Echinacea purpurea extract (Echinacea)

Echinacea is an herb with a long history of traditional use for supporting respiratory tract health. It has been shown to stimulate immune function and may have antioxidant potential to reduce oxidative damage associated with immune response.⁷ Multiple meta-analyses suggest that echinacea supports respiratory health, particularly in individuals with higher stress levels or immunological weakness.⁸

Vitamin D3

Vitamin D is synthesized in human skin when the compound 7-dehydrocholesterol is exposed to UVB light. Once thought to have the sole function of regulating calcium metabolism for bone health, it is now known that active Vitamin D3 plays a role in immune health. Vitamin D receptors are also found on both B- and T-cells of the immune system and may have the ability to adapt and modulate immune function.⁹

Zinc

Zinc is necessary for reproduction, growth and development, neurotransmission, vision, and immune function. One important function is immune modulation – the tamping down of the inflammatory immune response when it creates high levels of inflammatory mediators.¹⁰ In addition, zinc is believed to inhibit viral binding to ACE2 receptors on cell membranes where viruses latch on as a first step to invading cells. It also inhibits the functioning of viral replication enzymes, such as retroviral RNA replicase.¹⁰

Ginger (Zingiber officinale)

Ginger has a rich history of being used in both Ayurvedic and traditional Chinese herbal practices. Ginger’s oleoresin constituents exhibit potential inhibition of synthesis of prostaglandins and leukotrienes.¹¹ The components shogaol and paradol inhibit cyclooxygenase-2 enzyme activity dose-dependently, while gingerol inhibits 5-lipoxygenase.¹¹

The Benefits of Micellular Delivery

As an added bonus, micelles do not require digestive processes and instead float in-between the gap junctions within the intestinal lining for direct delivery into the body.  Micro-encapsulated delivery of vitamins and herbs offers multiple advantages over conventional peroral delivery of tablets and capsules. The liquid format is also helpful for patients who have difficulty swallowing tablets and capsules.

These patients may benefit from taking Micellular Immune Attune:

• Supports a healthy immune system response
• A food-based source of antioxidants, including anthocyanins and other naturally occurring polyphenols
• Vegan-sourced Vitamin D3 from plant sources
• Support regulation within normal levels of cyclooxygenase enzymes and other intermediary metabolites
• Supports overall cellular membrane integrity

Ingredients

• Vitamin C (as ascorbic acid) (120 mg)
• Vitamin D3 (from lichen) (50 mcg)
• Vitamin E (as D Alpha Tocopherol) (6.7 mg)
• Zinc (as Zinc Bisglycinate) (15 mg)
• Liposomal Proprietary Blend (non-GMO Sunflower oil containing Phosphatidylcholine) (4000 mg)
• Elderberry juice ext. (800 mg)
• Echinacea purpurea ext. (50 mg)
• Ginger (from Ginger oil) (10 mg)

Recommended Dosage

As a dietary supplement, take 15 ml (approx. 3 tsp) daily or as directed by your healthcare provider.

References

1. Hewison, M. (2011). Vitamin D and Innate and Adaptive Immunity. Vitamins & Hormones, 23–62.doi:10.1016/b978-0-12-386960-9.00002-2
2. Leichtmann, G. A., Bengoa, J. M., Bolt, M. J., and Sitrin, M. D. (1991). Intestinal absorption of cholecalciferol and 25-hydroxycholecalciferol in patients with both Crohn’s disease and intestinal resection. Am. J. Clin. Nutr. 54, 548–552
3. Vlachojannis JE, Cameron M, Chrubasik S. A systematic review on the sambuci fructus effect and efficacy profiles. Phytother Res. 2010 Jan;24(1):1-8. doi: 10.1002/ptr.2729. PMID: 19548290.
4. Zakay-Rones Z, Varsano N, Zlotnik M, Manor O, Regev L, Schlesinger M, Mumcuoglu M. Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of influenza B Panama. J Altern Complement Med. 1995 Winter;1(4):361-9. doi: 10.1089/acm.1995.1.361. PMID: 9395631.
5. Zakay-Rones Z, Thom E, Wollan T, Wadstein J. Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections. J Int Med Res. 2004 Mar-Apr;32(2):132-40. doi: 10.1177/147323000403200205. PMID: 15080016.
6. Tiralongo E, Wee SS, Lea RA. Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial. Nutrients. 2016 Mar 24;8(4):182. doi: 10.3390/nu8040182. PMID: 27023596; PMCID: PMC4848651.
7. Zhai Z, Liu Y, Wu L, et al. Enhancement of innate and adaptive immune functions by multiple Echinacea species. J Med Food. 2007;10(3):423-434. doi:10.1089/jmf.2006.257
8. Schapowal A, Klein P, Johnston SL. Echinacea reduces the risk of recurrent respiratory tract infections and complications: a meta-analysis of randomized controlled trials. Adv Ther. 2015 Mar;32(3):187-200. doi: 10.1007/s12325-015-0194-4. Epub 2015 Mar 18. PMID: 25784510.
9. Aranow C. Vitamin D and the immune system. J Investig Med. 2011;59(6):881-886. doi:10.2310/JIM.0b013e31821b8755
10. Margolin L, Luchins J, Margolin D, Margolin M, Lefkowitz S. 20-Week study of clinical outcomes of over-the-counter COVID-18 prophylaxis and treatment. J Evid Based Integr Med. 2021; 26: 2515690X211026193.
11. Mao QQ, Xu XY, Cao SY, et al. Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe). Foods. 2019;8(6):185. Published 2019 May 30. doi:10.3390/foods8060185