Adrenal Synergy supports the adrenal glands along with the HPA axis with a blend of glandulars, essential nutrients, and targeted botanicals. This comprehensive formula supports the neuro-endocrine pathways involved in the management of occasional stress.

Adrenal Synergy supports the adrenal glands along with the HPA axis with a blend of glandulars, essential nutrients, and targeted botanicals.
This comprehensive formula supports the neuro-endocrine pathways involved in the management of occasional stress.

Why Adrenal Synergy?

Using this one simple formula supports adrenal health and the
hypothalamic-pituitary-adrenal (HPA) axis. The adrenal glands and the
HPA axis play a critical role in managing the stress response. These
important functions also affect the neurobiology of mood disorders.
Adrenal Synergy is the ideal formula to help support the body in
dealing with symptoms of adrenal fatigue.

Daily Stress to Adrenal Fatigue

The human body has a very sophisticated mechanism for responding to
stress, calling on the nervous and endocrine systems for help. However,
with prolonged stress, these systems become exhausted, the necessary
neurotransmitters and hormones become depleted, and the body can
no longer maintain homeostasis. The body’s inability to cope with
stress is further exaggerated by poor diet and other lifestyle choices
such as the use of caffeine or alcohol and lack of exercise. Using a
blend of glandulars, essential nutrients, and targeted botanicals (along
with improved lifestyle decisions), Adrenal Synergy focuses on these
issues while supporting the neuro-endocrine pathways.

Micronutrients including vitamin C, zinc, vitamin B6
(p-5-phosphate), and folate (5-MTHF) are essential for
energy-producing pathways and serve as co-factors for synthesis of
adrenal hormones. Micronutrient supplementation has been shown to
improve the body’s response to stress in multiple clinical trials. In a
double-blind randomized study of 215 males receiving high-dose
micronutrient supplementation, subjects reported a reduction in
perceived stress scores and improvement in mood.1

Rhodiola rosea is an adaptogenic herb traditionally used to improve
mood, memory, and stamina across Asia and Eastern Europe. In a
placebo-controlled study, rhodiola rosea was shown to inhibit
elevations in cortisol when subjects were exposed to chronic stress in
the form of endurance. Rhodiola rosea is an adaptogenic herb
traditionally used to improve mood, memory, and stamina across Asia
and Eastern Europe. In a placebo-controlled study, rhodiola rosea was
shown to inhibit elevations in cortisol when subjects were exposed to
chronic stress in the form of endurance exercise.2 Rhodiola rosea is a
powerful tonic against anxiety, demonstrating an improvement in
symptoms among patients diagnosed with generalized anxiety
disorder.3 Rhodiola rosea may also improve the body’s utilization of
oxygen as well as protect cells from damage induced by oxidative
stress.4

Deglycyrrhizinated licorice (DGL) is an exceptionally useful herb in
managing adrenal function. Licorice blocks the breakdown of cortisol,
decreasing the body’s need to produce it. As cortisol demand
decreases, the adrenal glands are able to repair and restore normal
production of the other hormones. Licorice has also been shown to
increase DHEA, a critical anabolic hormone intermediary involved in the
production of estrogens and androgens.5

Ashwagandha (Indian ginseng) is a potent herb shown to improve
mood and support nervous system health. Ashwagandha has been
shown to modulate stress-induced changes related to
neurotransmitters, cortisol, metabolism, and HPA axis activity.6
Researchers are now evaluating its benefits in a variety of
neurodegenerative diseases due to its protective benefits on the
nervous system.7,8

Panax ginseng is an important adaptogenic herb used to ease mental
and physical exhaustion. It may help deplete the fatigue and lack of
energy experienced by adrenal fatigue patients. Panax ginseng also
encourages adrenal gland health in times of stress by maintaining
healthy levels of certain adrenal hormones, most notably,
corticosterone.9

Eleutherococcus is an adaptogenic herb used to support cognition,
mental alertness, and response to physical stress. Eleutherococus may
be of specific benefit in patients experiencing low immunity or suffering
from recurrent infections.10

Glandulars (pituitary, hypothalamus, thymus, adrenal) help to
regenerate the major organs involved in the stress response. Glandulars
help to rebuild tissues and balance body chemistry by providing the
substrates and materials needed by each specific organ.11

Ingredients

• Vitamin C (as ascorbic acid) (50 mg)
• Vitamin B6 (pyridoxal 5-phosphate) (1 mg)
• Folate (as methyltetrahydrofolic acid) (50 mcg)
• Pantothenic Acid (as d-calcium pantothenate) (50 mg)
• Zinc (as zinc AAC) (1 mg)
• Suprarenal Adrenal (Porcine) (50 mg)
• Suprarenal Cortex (Bovine) (100 mg)
• Organic Ashwagandha Root Extract (standardized 5% withanolides) (100 mg)
• Pituitary (Bovine) (100 mg)
• Rhodiola Root Extract (3% Rosavin, 1% Salidroside) (100 mg)
• Licorice Root (deglycyrrhizinated) Extract (3.0% Glycyrrhizinic Acid) (75 mg)
• Eleuthero Root Extract (0.8% Eleutheroside) (50 mg)
• Asian Ginseng Aerial Parts (8% Ginsenosides) (50 mg)
• Hypothalamus (Bovine) (50 mg)
• Thymus (Bovine) (30 mg)
• Alpha Lipoic Acid (5 mg)

Suggested Use

As a dietary supplement, take 2 capsules a day with meals or as directed by your healthcare professional.

Resources

1 Kennedy DO, Veasey R, Watson A, Dodd F, Jones E, Maggini S, Haskell CF. Effects of high-dose B vitamin complex
with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology (Berl).
2010 Jul;211(1):55-68.

2 Zhang ZJ, Tong Y, Zou J, Chen PJ, Yu DH. Dietary supplement with a combination of Rhodiola crenulata and Ginkgo
biloba enhances the endurance performance in healthy volunteers. Chin J Integr Med. 2009 Jun;15(3):177-83.

3 Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J
Altern Complement Med. 2008 Mar;14(2):175-80.

4 De Bock K, Eijnde BO, Ramaekers M, Hespel P. Acute Rhodiola rosea intake can improve endurance exercise
performance. Int J Sport Nutr Exerc Metab. 2004 Jun;14(3):298-307.

5 Al-Dujaili EA, Kenyon CJ, Nicol MR, Mason JI. Liquorice and glycyrrhetinic acid increase DHEA and deoxycorticosterone
levels in vivo and in vitro by inhibiting adrenal SULT2A1 activity. Mol Cell Endocrinol. 2011 Apr
10;336(1-2):102-9.

6 Gupta GL, Rana AC. Protective effect of Withania somnifera Dunal root extract against protracted social isolation
induced behavior in rats. Indian J Physiol Pharmacol. 2007;51:345-53.

7 Kuboyama T, Tohda C, Komatsu K. Neuritic regeneration and synaptic reconstruction induced by withanolide A. Br J
Pharmacol. 2005 Apr;144(7):961-71.

8 Tohda C, Kuboyama T, Komatsu K. Dendrite extension by methanol extract of Ashwagandha (roots of Withania
somnifera) in SK-N-SH cells. Neuroreport. 2000 Jun 26;11(9):1981-5.

9 Gaffney BT, Hügel HM, Rich PA. Panax ginseng and Eleutherococcus senticosus may exaggerate an already existing
biphasic response to stress via inhibition of enzymes which limit the binding of stress hormones to their receptors.
Med Hypotheses. 2001 May;56(5):567-72.

11 THE SCIENTIFIC BASIS OF ORGANOTHERAPY. JAMA. 1900;XXXV(23):1483–1484. doi:10.1001/jama.
1900.02460490041004