Thyroid and HPT Support
ThyroSyn provides nutrients, glandulars, and targeted herbals to support the thyroid and the HPT axis.
This comprehensive formula provides micronutrients, glandulars, and
targeted herbals to support one of the principal glands in the body.
Thyroid hormone production can be disrupted by several factors,
like environmental toxins, normal hormonal fluctuations
and nutrient deficiencies. Thyrosyn helps provide the body with
support for healthy thyroid activity.
A Small Gland with a Big Job!
The thyroid is a small gland located in the base of the neck. It has the
important role of controlling the metabolic rate for the entire body.
Thyroid hormones influence over 100 enzymes and are essential for
maintaining homeostasis. The thyroid makes two kinds of thyroid
hormone: thyroxine, or T4, which contains four iodine atoms, and
triiodothyronine, or T3, which contains three iodine atoms. T3 is made
from T4—one atom is removed in organs and tissues where T3 is used
the most, such as the liver, the kidneys, and the brain.
In a healthy thyroid, thyroid hormone as T4 (and some T3) is stored
within the thyroid follicles and released into the blood stream based
on the metabolic needs of the cells. This release is based on a delicate,
negative-feedback system that is dependent upon the pituitary and
hypothalamus, also referred to as the HPT (hypothalamic-
Iodine is an alkaloid compound found in several different plants and is
an essential component of thyroid hormones. Iodine deficiency can
cause severe disruption in thyroid hormone output. Though supplementing
with iodine can be beneficial, supplementing with excessive, high doses of
iodine can also be damaging to the thyroid gland or cause autoimmune
Selenium is probably the next most important mineral affecting
thyroid function. Selenium is an essential component of the enzymes
which convert T4 into T3, making it a key factor in thyroid hormone
activation. Selenium is also critical for protecting the thyroid gland from
the damage caused by excessive iodine accumulation.1
Tyrosine (as N-Acetyl L-Tyrosine) is an integral part of thyroid
hormone. Unlike L-tyrosine, N-Acetyl L-Tyrosine is water soluble leading
to greater absorption and better bioavailability.
Glandulars of Anterior Pituitary, Hypothalamus, and Thyroid help
to regenerate the major organs involved in the HPT axis. This delicate
neuroendocrine pathway works to maintain body homeostasis through
a tightly regulated negative-feedback system.2
Ashwagandha (Indian Ginseng) is an Ayurvedic herb which may
have profound effects on balancing thyroid and adrenal activity. In mice
models, ashwagandha has been shown to increase levels of T4,
indicating it may stimulate a sluggish thyroid.3 Ashwagandha has been
shown to modulate stress-induced changes related to
neurotransmitters, cortisol, metabolism, and HPT axis activity.4
Milk thistle is a well-studied herb with multiple medical applications.
Though not known to have a direct effect on the thyroid, milk thistle is
known to support liver function. This is of special interest to patients
who suffer from high levels of reverse T3. With healthy thyroid
function, the body converts T4 to active T3. However, in times of
stress, nutrient deficiencies, or when the toxic load is high, the
body may convert to T4 to reverse T3. Improper conversion to this
unusable form of T3 is a common, often undiagnosed hypothyroid
1 Zimmermann MB, Köhrle J. The impact of iron and selenium deficiencies on iodine and thyroid metabolism: biochemistry and relevance to public health. Thyroid. 2002 Oct;12(10):867-78.
2 Dietrich JW, Landgrafe G, Fotiadou EH. TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis. Journal of Thyroid Research. 2012: 351864.
3 Pradhan SC, Girish C. Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian Journal of Medical Research. 2006 Nov;124(5):491-504.
4 Gupta GL, Rana AC. Protective of Withania somnifera Dunal root extract against protracted social isolation induced behavior in rats. Indian J Physiol Pharmacol. 2007;51:345-53.
5 Johannes J., Jayarama-Naidu R., Meyer F., Wirth E. K., Schweizer U., Schomburg L., et al. (2016). Silychristin, a Flavonolignan Derived from the Milk Thistle, Is a Potent Inhibitor of the Thyroid Hormone Transporter MCT8. Endocrinology 157, 1694–1701. 10.1210/en.2015-1933 – DOI – PubMed
- Iodine (from kelp) (50 mcg)
- Selenium (as Selenomethionine) (50 mcg)
- Thyroid (Thyroxine Free) Bovine (300 mg)
- N Acetyl L Tyrosine (125 mg)
- Ashwaganda Powder (75 mg)
- Anterior Pituitary, Bovine (50 mg)
- Hypothalamus (50 mg)
- Milk Thistle Seed Extract (50 mg)
As a dietary supplement, take 2 capsules daily or as recommended by your healthcare professional.