Thyroid and HPT Support

60 Caps/Bottle

Additional Information

ThyroSyn provides nutrients, glandulars, and targeted herbals to support the thyroid and the HPT axis.

Why ThyroSyn?


This comprehensive formula provides micronutrients, glandulars, and

targeted herbals to support one of the principal glands in the body.


Thyroid hormone production can be disrupted by several factors,

like environmental toxins, normal hormonal fluctuations

and nutrient deficiencies. Thyrosyn helps provide the body with

support for healthy thyroid activity.


A Small Gland with a Big Job!


The thyroid is a small gland located in the base of the neck. It has the

important role of controlling the metabolic rate for the entire body.

Thyroid hormones influence over 100 enzymes and are essential for

maintaining homeostasis. The thyroid makes two kinds of thyroid

hormone: thyroxine, or T4, which contains four iodine atoms, and

triiodothyronine, or T3, which contains three iodine atoms. T3 is made

from T4—one atom is removed in organs and tissues where T3 is used

the most, such as the liver, the kidneys, and the brain.


In a healthy thyroid, thyroid hormone as T4 (and some T3) is stored

within the thyroid follicles and released into the blood stream based

on the metabolic needs of the cells. This release is based on a delicate,

negative-feedback system that is dependent upon the pituitary and

hypothalamus, also referred to as the HPT (hypothalamic-

pituitary-thyroid) axis.


Iodine is an alkaloid compound found in several different plants and is

an essential component of thyroid hormones. Iodine deficiency can

cause severe disruption in thyroid hormone output. Though supplementing

with iodine can be beneficial, supplementing with excessive, high doses of

iodine can also be damaging to the thyroid gland or cause autoimmune



Selenium is probably the next most important mineral affecting

thyroid function. Selenium is an essential component of the enzymes

which convert T4 into T3, making it a key factor in thyroid hormone

activation. Selenium is also critical for protecting the thyroid gland from

the damage caused by excessive iodine accumulation.1


Tyrosine (as N-Acetyl L-Tyrosine) is an integral part of thyroid

hormone. Unlike L-tyrosine, N-Acetyl L-Tyrosine is water soluble leading

to greater absorption and better bioavailability.


Glandulars of Anterior Pituitary, Hypothalamus, and Thyroid help

to regenerate the major organs involved in the HPT axis. This delicate

neuroendocrine pathway works to maintain body homeostasis through

a tightly regulated negative-feedback system.2


Ashwagandha (Indian Ginseng) is an Ayurvedic herb which may

have profound effects on balancing thyroid and adrenal activity. In mice

models, ashwagandha has been shown to increase levels of T4,

indicating it may stimulate a sluggish thyroid.3 Ashwagandha has been

shown to modulate stress-induced changes related to

neurotransmitters, cortisol, metabolism, and HPT axis activity.4


Milk thistle is a well-studied herb with multiple medical applications.

Though not known to have a direct effect on the thyroid, milk thistle is

known to support liver function. This is of special interest to patients

who suffer from high levels of reverse T3. With healthy thyroid

function, the body converts T4 to active T3. However, in times of

stress, nutrient deficiencies, or when the toxic load is high, the

body may convert to T4 to reverse T3. Improper conversion to this

unusable form of T3 is a common, often undiagnosed hypothyroid



1 Zimmermann MB, Köhrle J. The impact of iron and selenium deficiencies on iodine and thyroid metabolism: biochemistry and relevance to public health. Thyroid. 2002 Oct;12(10):867-78.

2 Dietrich JW, Landgrafe G, Fotiadou EH. TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis. Journal of Thyroid Research. 2012: 351864.

3 Pradhan SC, Girish C. Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian Journal of Medical Research. 2006 Nov;124(5):491-504.

4 Gupta GL, Rana AC. Protective of Withania somnifera Dunal root extract against protracted social isolation induced behavior in rats. Indian J Physiol Pharmacol. 2007;51:345-53.

5 Johannes J., Jayarama-Naidu R., Meyer F., Wirth E. K., Schweizer U., Schomburg L., et al. (2016). Silychristin, a Flavonolignan Derived from the Milk Thistle, Is a Potent Inhibitor of the Thyroid Hormone Transporter MCT8. Endocrinology 157, 1694–1701. 10.1210/en.2015-1933 – DOI – PubMed


  • Iodine (from kelp) (50 mcg)
  • Selenium (as Selenomethionine) (50 mcg)
  • Thyroid (Thyroxine Free) Bovine (300 mg)
  • N Acetyl L Tyrosine (125 mg)
  • Ashwaganda Powder (75 mg)
  • Anterior Pituitary, Bovine (50 mg)
  • Hypothalamus (50 mg)
  • Milk Thistle Seed Extract (50 mg)

Suggested Use

As a dietary supplement, take 2 capsules daily or as recommended by your healthcare professional.

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