Dietary Supplement

60 Plant-Source Capsules
Comprehensive Support for Circulation and Arterial Health*
  • Scientifically formulated with nattokinase and diosmin
  • Clinically targets arterial health*
  • Promotes healthy microcirculation and blood flow*
  • Maintains healthy fibrinolytic activity*
  • Supports healthy clotting function*
  • Comprehensive cardiovascular and circulatory health support*
  • Helps maintain healthy blood pressure already in the normal range*

Comprehensive support for circulation, healthy clotting function and clinically targeting arterial health*

Technical Bulletin



Additional Information

Circuzyme™ contains citrus-sourced diosmin, a type of plant chemical used to target blood vessel support.* Diosmin may help support healthy microcirculation of blood including supporting a healthy inflammatory response.*

This superior formula also contains key amino acids propionyl l-carnitine and l-arginine. These amino acids make up the building blocks of proteins, making them critical to whole-body health.* This blend of diosmin and amino acids work synergistically to promote healthy microcirculation of blood to peripheral tissues.*

In a multicenter prospective study, Corsale, Carrieri, Martellucci, et al., (2018) evaluated a flavonoid mixture (diosmin, troxerutin, rutin, hesperidin, quercetin) 2 of the main products found in CircuZyme.  They found the flavonoid mixture reduced hemorrhoidal bleeding on 154 patients and found this mixture safe and effective to manage bleeding from hemorrhoidal disease with minimal adverse events. 

Hesperidin is a flavone glycoside found in citrus fruit such as lemons and sweet oranges. The  pharmacological activities of Hesperidin include anti-atherogenic, antihyperlipidemic, antidiabetic, venotonic, cardioprotective, anti-inflammatory, and antihypertensive actions [1].  Haggaga, Y., El-Ashmawyb, N., Okasha, K. explored the anti-viral properties of Hesperidin as a potential prophalactic to support against viruses, including Covid-19.



Serving Size 2 Capsules
Servings Per Container 60 

Amount Per Serving:

  • Proprietary Blend  800 mg
    • L-Arginine, Diosmin (citrus source), Propionyl L-Carnitine, Tocotrienols (predominately delta and gamma fractions), Organic Cranberry (fruit), Organic Olive Leaf (Olea europaea), Organic Noni (fruit) (Morinda citrifolia), Bear Garlic (leaf) (Allium ursinum), Chrysin, Hesperidin (natural orange extract), Organic Chlorella (whole; broken cell wall) (Chlorella sorokiniana), Organic Turmeric (rhizome) (Curcuma longa), Organic Cayenne (fruit) (Capsicum annuum), Organic Fermented Cordyceps (mycelia) Extract (Cordyceps sinensis), Nattokinase
Other Ingredients: Plant-Source Capsules (cellulose, water), Non-GMO Maltodextrin

Recommended Usage

Take 2 capsules, 3 times daily or as directed by a health professional.


[1]. Haggag, Yusuf, A., El-Ashmawy, N., Okasha, (June 6, 2020), Is Hesperidin essential for prophaylaxis and treatment of Covid-19 Infection? Medical Hypothesis.  Doi: 10.1016/j.mehy.2020.109957.

[2]. Corsale I, Carrieri P, Martellucci J, Piccolomini A, Verre L, Rigutini M, Panicucci S.  Flavonoid mixture (diosmin, troxerutin, rutin, hesperidin, quercetin) in the treatment of I-III degree hemorroidal disease: a double-blind multicenter prospective comparative study. J Colorectal Dis. 2018 Nov;33(11):1595-1600. doi: 10.1007/s00384-018-3102-y. Clinical Trial.


This product is not intended to treat or diagnose disease.  

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